This game is developed by Beenox, the same developers who brought you the previous games - Spiderman: Shattered Dreams, and Spiderman: Edge Of Time. The plot revolves around our favourite web aficionado Spiderman, for whom there is always danger awaiting in his beloved Manhattan, and of course there's a particular trouble afoot. An Oscorp executive with the help of Michael Morbius (a human afflicted with vampiric powers after a science experiment gone awry) gain access to the research of Dr.

Curt Connors (otherwise known as the Lizard); research that depicts how to create a hybrid of a man and a rhinoceros.